As a professor at the Ajou University School of medicine, I am delighted to have the opportunity to participate in the upcoming Lupus & KCR 2023 conference and share my research on the proteomics of autoimmune disease. I hold a Ph.D. from Hanyang University and have had the privilege of receiving postdoctoral training at Johns Hopkins University School of Medicine.
My presentation, entitled "Proteomics for Autoimmune Disease," will unveil our pioneering research in identifying reliable biomarkers for systemic lupus erythematosus (SLE) using a high-throughput protein microarray-based technology. By analyzing blood samples from both SLE patients and healthy controls, we were able to identify 63 autoantibody groups that were exclusively detected in SLE patients. Among these groups, we focused on the SMYD3 autoantibody, which demonstrated the highest detection rate.
To validate the potential of SMYD3 autoantibodies as a diagnostic marker, we purified the SMYD3 autoantigen and conducted ELISA tests on blood samples from a sample population of 200 individuals, including healthy controls, SLE patients, rheumatoid arthritis patients, psoriasis patients, and Behcet's syndrome patients. Our results indicate that SMYD3 autoantibodies possess a specificity of 89% for detecting SLE in blood samples, underscoring the tremendous potential of these autoantibodies as a diagnostic biomarker for SLE among various autoimmune diseases.
I am honored to share these novel findings and insights with esteemed colleagues and experts in the field at the Lupus & KCR 2023 conference. Thank you for your consideration of my presentation, and I look forward to engaging with fellow attendees and contributing to the advancement of the field of autoimmune disease research.
Ho Chul Kang
Room Grand Ballroom 105
[Workshop] Basic Research Workshop for Rheumatologist: Translational Research of Rheumatic Diseases